Jobo's usual suggestion is that the reels have been contaminated with wetting agent or stabilizer which is extremely difficult to wash off and that causes the development irregularities. I don't know how valid that is, but a brand-new 2502 reel might be worth a try if you haven't already done so.(posted 8162 days ago)Dilute developers often work better; you might try diluting the Microdol-X 1:3. About 1.5x the normal development time would be a reasonable starting point.
And that brings up a question; why Microdol-X?